Noopept Review: Dosage, Benefits, Stack and Side Effects (2019)
Noopept is a relatively recent nootropic on the market. It is touted as a treatment for everything from anxiety to traumatic brain injuries, dementia, and diabetes. Here, we’ll explain what Noopept is before discussing the benefits and side effects of Noopept. We’ll share recommendations on Noopept dosage for various situations and where Noopept may fit in your nootropic stack.
What Is Noopept?
Noopept is a “nootropic,” a drug or supplement that in some way improves cognitive function. A nootropic could enhance problem-solving abilities, memory, creativity, motivation or mental function in general. Noopept can stimulate mental capacity. It is considered several hundred times more effective than Piracetam. It is similar to Racetam, an NMDA receptor modulator, and it shares similarities with Ampakine, an AMPA glutamate receptor modulator.
The chemical name for Noopept is N-Phenylacetyl-L-prolylglycine ethyl ester. Noopept is the brand name it is sold under. It is sometimes called Noopeptide or GVS-111. It is not really a racetam molecule since it lacks a 2-oxo-pyrollidine skeleton, but it is sometimes thrown in the racetam category. Instead, it is an unrelated dipeptide to piracetam, though it was designed with the structure of piracetam in mind.
Noopept was first synthesized in 1996. It can be considered a peptide-based molecule, and it was created specifically to treat cognitive decline in the elderly. It has been prescribed in Russia since that time but only recently came to the United States. It has become one of the more popular “smart drugs” in the U.S., featured in articles about how Silicon Valley professionals try to maximize their productivity and creativity.
What Are the Benefits of Noopept?
Noopept binds to the glutamatergic AMPA receptor site in the brain, allowing glutamate to flow between cells more efficiently. Glutamate is one of the most important neurotransmitters in the brain. Improve the flow of this critical neuro-chemical, and you’ll see an improvement in cognitive abilities like executive function, the fancy term for problem-solving and complex decision-making ability. It upregulates neurotropin factors like BDNF (brain-derived neurotrophic factor) and NGF, chemicals involved in long-term memory and neurogenesis (the formation of new neurons).
Taken regularly, it can improve your memory and concentration. It stimulates alpha brain wave function in a way that provides calm alertness.  More research is needed to determine if noopept’s ability to excite neurons makes it a viable focus enhancer or “psychostimulant,” though it is often sold as such. For example, animal studies show that it stimulates specific neurons but doesn’t necessarily excite them. 
You could improve how quickly you learn things and can recall the information when needed by taking Noopept. In theory, this could help ward off dementia. The enhanced neuroplasticity linked to Noopept use could help older people retain their ability to learn new things as well as recall information.
The compound is similar to antioxidants in helping protect the brain from stress. This anti-oxidation effect could protect neurons from degeneration due to age. Studies in animals suggest it may be able to reverse the harmful effects of alcohol abuse. There isn’t substantial evidence that Noopept could reverse the mental deterioration linked to alcoholism or drug abuse, but the studies of those recovering from concussions and strokes suggest it may be able to help in these cases.
It doesn’t really affect motivation, energy or endurance. It is not a mood enhancer for most people. The only study in humans that found any benefit for those with depression was a study seeking to minimize the long-term harm from concussions and strokes. The study found that those who received Noopept had less depressive symptoms over the two-month timeframe of the research that those who took other drugs or didn’t receive treatment at all. It is better than piracetam in moderating the anxiety these patients felt.
It doesn’t seem to improve the quality of sleep or help people get to sleep in the first place. It is generally recommended not to take Noopept at night since the increased brain activity could interfere with your ability to sleep.
In theory, it can reduce emotional sensitivity after a brain injury, whether you suffered a concussion or a stroke. That idea was further reinforced by a study done a few years ago.  Those who took 20 milligrams of Noopept had higher global MMSE scores than those who took 1200 milligrams of Piracetam. Interestingly, Noopept helped both those with amnesia and brain fog after a concussion as well as those with vascular-related deficits, while Piracetam only helped those with brain damage due to cerebrovascular insufficiency.
Noopept has been shown to protect neurons from deterioration when the animals suffered hypoxia, and it is reasonable to assume it would have a similar protective effect in humans.  Common causes of this condition include but are not limited to altitude sickness, reduced blood flow due to cardiovascular problems, respiratory problems, and conditions like emphysema. A potential justification for taking Noopept will be to stave off mental deterioration if you’re afraid you have sleep apnea. Some data is suggesting Noopept would protect neurons from excitotoxicity, calcium overload, mitochondrial damage, inflammation, and ionic dis-balance.  In a 2014 study, the protective effects were seen along with restorative effects in animal models for Alzheimer’s disease. We can’t say that taking Noopept will prevent Alzheimer’s disease, but it could slow its progress and limit the associated damage the disease causes. If you’re taking medications or have a medical condition that causes excitotoxicity, Noopept should be in your stack to protect your brain.
Noopept has been shown to improve how often neurons in lab rats’ hippocampus generate calcium transients in neurons. Yet it does this without altering the calcium concentration in the cell.  You get increased mental function without potentially throwing brain chemistry out of whack.
There is experimental evidence that Noopept helps the brain grow new neurons or strengthens damaged ones in the hippocampus, though that is entirely from animal studies.  However, there is no evidence that Noopept boosts brain growth in healthy children or adults.
Noopept has been shown to alleviate amyloid oligomeric cytotoxicity.  This reduces the degenerative effects of Parkinson’s disease since the cells appear to be normalized relative to healthy cells. Furthermore, Noopept improves the viability of neurons exposed to toxic levels of glutamic acid. 
Noopept increased immunoreactivity to Aβ amyloid in mice with Alzheimer’s disease.  However, there has not been any study of this in humans. There is data suggesting it minimizes the damage associated with scopolamine injections, frontal lobectomy, and cerebral hypoxia. 
What Is the Right Noopept Dosage?
Noopept is available in pills and powdered form. Putting the pill or powder under your tongue causes it to get to the brain even faster.
Because it is so powerful, you need far less of it than comparable nootropics. The standard dose is ten to thirty milligrams. For those just starting out, the recommended noopept dosage is 10 milligrams twice a day. Once your body builds up a tolerance, you can increase your dosage to 30 milligrams a day, whether you take 10 mg three times a day or 15 mg twice a day. Those who want the stimulating effect should take higher doses less frequently, while those who want to maximize the protective benefits should take a lower dose more often. This is because the mental enhancement effects were concentration-dependent.  Do not take more than 40 milligrams in a 24 hour period.
The drug is readily absorbed through the digestive tract and can pass the blood-brain barrier in as little as fifteen minutes. Taking a higher dose increases the odds of gastrointestinal upset and headache.
How Does Noopept Fit Into a Stack?
Noopept is sometimes combined with racetams since they’re so different chemically. You can mix or “stack” Noopept with Piracetam, Phenylpiracetam or Aniracetam. A few people combine it with oxiracetam or coluracetam.
Another option is stacking noopept with a choline supplement to prevent the headaches and irritability that often come with it. Noopept is sometimes combined with alpha gpc. There is only anecdotal evidence that it has any impact when combined with centrophenoxine, a new cholinergic.
Noopept should be combined with multivitamins if you aren’t eating a healthy diet. Taking antioxidants in addition to Noopept has an amplified, protective effect on the brain. This is especially true if you’re suffering memory lapses, trouble concentrating, a reduced rate of learning and other cognitive issues linked to an injury or health problem. 
Since Noopept is a synthetic peptide, there are some who try to combine it with natural nootropics. For example, Noopept is periodically combined with pine bark extract or bacopa in those seeking to improve learning and memory. Noopept is sometimes combined with Gotu kola or ashwagandha to improve overall mental function. There is no evidence it is dangerous if combined with herbs and traditional remedies like green tea or gingko.
What Are Potential Noopept Side Effects?
Noopept is known to cause mild headaches, especially for new users. Irritability is another common side effect. You can offset these side effects by taking multivitamins and working out regularly. Some people taking Noopept have said it made them anxious or contributed to nausea. However, it is literally better than the alternative. Scientific studies have found that those taking Piracetam experienced 1.8 times as many side effects as Noopept.
Noopept side effects for those with brain trauma like concussions had trouble sleeping, irritability and increased blood pressure.  Conversely, Noopept isn’t really recommended for healthy people, while all of the proven benefits are limited to those with a demonstrable neurological decline for some reason.
The Noopept stack is not recommended for women who are pregnant or nursing. There just isn’t enough information to prove it is safe in these cases. However, animal studies suggest this supplement shouldn’t be given to growing children. Healthy rat pups injected with the substance suffered impaired memory function, though it didn’t affect their locomotion.
If you have ADHD or otherwise have trouble focusing, there are advantages to trying Noopept. Nootropics like Noopept are not addictive the way stimulants like Adderall are. A bright point in favor of Noopept is that it won’t cause dangerous side effects like heart problems or high blood pressure if you combine it with ADHD drugs.
Noopept side effects tend to be limited by its small dosage. For example, people take so little at a time that it rarely irritates the stomach. Animal studies suggest that a toxic dose for humans could be as high as 170 milligrams for a 70-kilogram adult.
Through animal studies failed to find any risk of allergic reactions or direct health effects associated with this nootropic. That makes Noopept far safer than many herbal remedies that are not recommended for those with liver problems, kidney problems or diabetes. There is tentative evidence that Noopept helps normalize the incretin system in rats.  However, no one recommends Noopept as a treatment for diabetes, pre-diabetics or metabolic syndrome. The beauty of Noopept, though, is that it is safe for nearly everyone to take.
Noopept stands out as one of the safest nootropics for protecting the brain. You can see significant benefits at very low doses, and it can be safely combined with a variety of nootropics. It is demonstrably effective at limiting the long-term damage to the brain in cases of trauma, while there is fair evidence it is beneficial if you’re dealing with a degenerative condition or mental decline due to aging. Given its relative novelty in the West, there isn’t a lot of hard data on the drug though there’s plenty of anecdotal information. Perhaps the best proof of its safety and effectiveness is that it is regularly prescribed to patients in the country it originated from – Russia.
 EEG showing calm alertness
 Noopept for those with strokes and concussion
 Noopept stimulates new neuron growth and protects existing ones
 Noopept in Parkinson’s disease
 Noopept and Alzheimer’s in mice
 Anti-oxidative stress protection
 Protection after lobectomy
 Noopept protects neurons from the toxicity of glutamic acid
 protective effect in hypoxia
 normalizes incretin system
 stimulates but doesn’t excite specific neurons
 Concentration affects effectiveness
 Cellular model shows general neuroprotective effect
 Improved calcium transients