5 Best Nootropics for Depression that Work Fast

Many people today are finding it difficult to cope with everyday issues like lack of jobs, money, and a weak economy. In the UK, around 1 in 4 people experience mental health problems such as depression and anxiety every year. The ADAA (Anxiety and Depression Association of America) claims that the most common mental illness that affects 18.1% of the US population is anxiety disorders. Anxiety disorders also coincide with various ailments such as eating disorders, depression, and ADHD.

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The advantage is that these disorders are treatable through therapy and medication. A person suffering from depression can deal with it by taking prescribed pills or herbs. In recent times, people have been taking nootropics for depression. But before looking at what nootropics are, it is first essential to know what causes depression.

What causes depression?


Nobody knows what causes depression. The disorder can have several psychological issues like trauma, personal hardship, and abuse. Also, a chemical imbalance in a person’s brain can cause depression.

A person with this disorder may also suffer from hormone deficiencies due to genetics, aging, or the environment. These deficiencies can cause communication problems, hopelessness, difficulty coping with problems, and mood swings.

Traditionally, people have been using anti-depressants to treat depression. These drugs work by balancing serotonin levels in the brain, and some nootropics work in the same way too. However, others concentrate on dopamine, a neurotransmitter present in the body.

Low dopamine levels are dangerous and may cause poor energy and laziness. By balancing or boosting these levels, it can help to lessen depressive symptoms.

Taking mood enhancers and nootropics for severe depression is common nowadays. However, the challenge most people face is identifying which nootropics they should take and the possible side effects linked with them.

Generally, a person suffering from occasional or mild depressive symptoms should try nootropics. They are also ideal for people looking for mood boosters. But what are the best nootropics for depression?

5 Best Nootropics for Depression

1. L-Tyrosine

L-Tyrosine is an amino acid the body uses to synthesize dopamine. Its function is to support the adrenal glands that produce epinephrine and dopamine, hence ensuring effective body function and health. By increasing or producing more dopamine levels, this can help to boost mental energy, enjoyment, motivation, and appetite. All of these can help a person cope with depressive episodes.

L-Tyrosine also helps to balance norepinephrine, a chemical that controls mood and stress. If the body has low levels of norepinephrine, a person will suffer from physical stress and anxiety. Furthermore, it may lead to conditions like depression, ADHD, and hypotension.

L-Tyrosine is essential in the body because it promotes the steady re-absorption of norepinephrine, thus ensuring a proper balance of the hormone. A person can gain L-Tyrosine from supplementation and various food sources like poultry, nuts, and dairy foods. Note that supplementation is only useful if needed for extreme cases.

By taking this nootropic, a person suffering from depression can manage their life both in the short and long-term, and experience a shift in mood and energy. Daily intake of L-Tyrosine can also prevent mild depressive sequences before they happen.


Dosages can vary from person to person. However, it is best to consume low dosages if one is experiencing mild depressive episodes. For first time users, the correct dosage to start with is 100 mg.

Many people end up taking up to 500 mg a day. Patients should only take high dosages on an as-needed basis. A 100 mg dosage is enough to help improve mood and energy. Note that high doses of L-Tyrosine can over-stimulate the body and cause stomach upset and nausea.

It is also important to be aware that the nootropic may have various theoretical interactions if taken with certain substances and medications. As such, visiting a doctor before taking the nootropic is highly recommended.

Summary: L-Tyrosine is an amino acid involved in the production of adrenaline and dopamine, which makes it the great and effective nootropic for depression. L-Tyrosine can help to improve memory, mood, energy, alertness, and learning, especially in stressful situations.

2. Bacopa Monnieri

Bacopa Monnieri is one of the most effective nootropics for severe depression. It is a nootropic herb traditionally used as medicine for cognitive enhancement and longevity. Frequent supplementation of this Ayurvedic herb can help to slow down the aging process of the brain and improve memory formation. Moreover, the nootropic can help reduce depression and anxiety.

Bacopa Monnieri is in a class of chemicals known as adaptogens. At a chemical level, adaptogens work by blocking stress messages before they can produce stress episodes in the body. These adaptogens are always effective when taken before a stressful situation occurs.

The herb’s extract is also an important supplement for people suffering from anxiety and depression symptoms. It can create calm mental situations by soothing jangled nerves. Bacopa Monnieri also offers effective therapy for a person with ADHD as well as those with conditions where hyperactive brain distracts them from their normal activities.

For daily use, this nootropic remains the best for boosting learning and memory. These two properties make it a popular supplement among students and people of all ages. People can also use it as a possible treatment for slowing down the Alzheimer’s symptoms.

Bacopa Monnieri has many anti-inflammatory properties. Inflammation tends to cause most chronic disorders, such as arthritis. When inflammation occurs, it can lead to weight gain, reduced organ function, and tissue damage. To end any chronic pain in muscles and joints and cut inflammation, a person can use Bacopa Monnieri as a remedy.

As noted above, this Ayurvedic herb is suitable for people of all ages. School children can take the supplement before the start of lessons to boost memory and learning. The elderly can use it to offset cognitive losses linked with aging.


The standard dosage for Bacopa Monnieri is 300 mg per day. While this may seem high, it does not cause significant side effects to the body. However, first-time users should always take note of how their stomach reacts after taking the supplement at this dosage.

It is worth mentioning that while this nootropic can improve memory and learning, it tends to work slowly. The slow action of the supplement can make it easy for people to add to their initial dosage thinking that it is not working. Adding to the dosage is a mistake that could lead to severe side effects. When taking the supplement, one should give it time to react, perhaps 2-3 hours.

Summary: Bacopa Monnieri is known as an adaptogen that blocks stress messages which makes it powerful nootropic for depression. It is a safe Ayurvedic herb that works slowly to reduce inflammation and pain.

3. 5-HTP

5-HTP is an amino acid and a natural anti-depressant produced in the body. It is also a chemical by-product of the essential amino acid L-tryptophan. As one of the most effective nootropics for depression treatment, 5-HTP is a remedy for depression, anxiety, migraines, fibromyalgia, and sleep disorders.

The nootropic works by increasing the production of serotonin in the brain, a happy neurotransmitter that regulates mood. Low levels of serotonin can cause anxiety and depression. As such, the body needs to produce more serotonin to fight depression.

As a naturally occurring compound, it is also included in many supplements to alleviate stress and boost mood. Users can take this nootropic to enhance focus and promote relaxation.

Recent studies show that 5-HTP can help with weight loss. The nootropic can help to increase the feelings of fullness, helping a person eat less.


Doses of between 50 mg and 3,000 mg a day for 2-4 weeks can eliminate depression symptoms.

For daily use, a dose of 300-500 mg is ideal. One can also take lower doses of 50 mg which will still help to fight depression.

Summary: 5-HTP offers a simple way of increasing levels of brain serotonin. In addition to helping with depression and sleep disorders, this nootropic can help with weight loss.

4. Aniracetam


Aniracetam is a smart drug or a nootropic supplement that can enhance cholinergic neurotransmission and promote cognitive function. When taken, the supplement reduces anxiety feelings by presenting the anxiolytic effect. It also improves mood together with focus and memory.

The supplement can reduce distractibility and improve a person’s mental focus. It can increase attention span and help people concentrate and focus quickly.

The supplement also works to improve the mental fluidity in users. By doing so, users can do simple and routine tasks like writing and reading easily.

Aniracetam also demonstrates various action mechanisms for promoting the benefits of anxiety, mood, and depression. Its anxiolytic effect is attributed to the supplement’s ability to produce GABA receptors in a person’s brain.


The recommended daily dosage is 600 mg to 1,500 mg. First-time users should not start with high dosages until they gauge their tolerance to the medication.

But to get the benefits of the supplement, patients should consider taking 1.5 grams of the nootropic by splitting it between three times daily.

It is also advisable to take the supplement at least 15 minutes after having a meal high in good fats (egg yolks, almonds, fish oil, and salmon).

Summary: Taking Aniracetam can help in improved focus and concentration. As one of the top nootropics for depression, Aniracetam has mood-boosting qualities, and people can use it to decrease depression symptoms.

5. Ginkgo Biloba

Ginkgo Biloba is one of the top natural nootropics for depression. It is a natural supplement that can help reduce depression, improve mental clarity, and memory. People can also use it to reduce anxiety and lessen fatigue.

The natural supplement can treat depression symptoms like suppressed appetite, mood disturbances, and poor sleeping patterns. It is also an effective treatment for dementia, poor concentration, schizophrenia, and anxiety disorders.

Ginkgo Biloba derives its power by increasing blood circulation in the body and brain. When there is less blood in the brain, this leads to cerebrovascular insufficiency. The condition also leads to other nervous system problems like stroke. Poor blood circulation in the brain can lead to memory lapses, concentration difficulties, and headaches.


Although people have used this natural nootropic supplement for long, Western medicine is yet to approve it for medical use and treatment. As such, it can be difficult to determine the correct dosage for the supplement. But as a general guideline, and to ensure safety, users should consume between 120 and 600 mg of the supplement per day.

Summary: Ginkgo Biloba is a natural nootropic supplement that enhances blood circulation in the brain to help boost memory. The supplement is a great remedy that has been used for centuries to treat depression, anxiety, and poor sleeping patterns.


Nootropics serve as the perfect alternatives to traditional anti-depressant medications. If you are feeling depressed, you can take a nootropic to boost your energy, improve your memory, and motivation.

Although some nootropics for depression treatment do not have side effects, it is essential to be cautious when taking them. Always remember to start with low dosages to prevent side effects.

Also, understand that you can only eliminate depression by identifying its cause. But whichever nootropic supplement you buy, experiment with it to determine its effect on you.

A big part of depression is feeling really lonely, even if you’re in a room full of a million people.
— Lilly Singh