Best 8 Benefits of Bioperine and Piperine Supplements (SELECTED)
Bioperine and piperine supplements have existed for years, but they’ve exploded onto the scene recently. These compounds have become the focus of some scientific studies. This allows us to discuss the proven benefits of Bioperine supplements and piperine supplements. We’ll stick to the best 8 benefits of Bioperine and piperine supplements.
What Are Bioperine and Piperine?
Piperine is a beneficial ingredient naturally found in black pepper. In fact, piperine is the substance that makes black pepper so spicy. Bioperine is a trademarked brand name for a piperine supplement made by Sabinsa Corporation. Someone talking about Bioperine is always talking about Piperine, though Piperine is available through many manufacturers. Take piperine from any source, and you’ll reap the many benefits of this compound. Bioperine stands out from the competition because it is 95% piperine. Nor do they mix piperine with equal amounts of curcumin from turmeric. But what are the health benefits of taking piperine? We’ll list the top 8 benefits of Bioperine and piperine supplements, though there are many more.
Summary: All Bioperine is piperine, but not all piperine is Bioperine.
1. Improved Nutrient Absorption
A public Bioperine benefit is enhanced nutrient absorption. If you consume piperine supplements, you’ll be able to absorb a more significant percentage of the nutrients in your food. For example, Bioperine increases the absorption of curcumin.  If you have been advised to take curcumin, you can receive a much higher benefit from curcumin with a lower dose when combined with piperine.  That amplifies curcumin’s ability to protect the brain.
That is aside from the fact that black pepper has long been prescribed as a treatment for digestive problems. A clear benefit of taking Bioperine supplements over adding more black pepper to your potatoes is that you’ll be better able to tolerate the higher dose. Piperine is an antioxidant in its own right, something that is hard to overdo. A 2010 article in "Journal of Ayurveda and Integrative Medicine" suggested that piperine may help those with malnutrition and health conditions that interfere with proper absorption of nutrients could benefit from Bioperine supplements. This includes but is not limited to Crohn’s disease, celiac disease, cystic fibrosis, chronic liver disease, short-bowel syndrome and diseases that affect the pancreas. It can also result from taking antibiotics for a long time, intestinal surgery or carrying an intestinal parasite. In other cases, the medication you choose for a health problem can interfere with the body’s ability to absorb various nutrients. Cholesterol drugs are among the primary culprits here. Diabetes, hyperthyroidism, and hypothyroidism can have the same result.
Note that chronic and especially loose or watery diarrhea can be a symptom of a health problem causing malabsorption of nutrients.
Summary: Piperine supplements can improve the absorption of medications and vital nutrients.
2. Reduced Inflammation
Bioperine supplements reduce inflammation in the body. It directly impacts the levels of cytokines that promote inflammation like IL-1b and PGE2. This may be why Indian medicine used black pepper to treat heart disease. In animal studies, piperine was found to reduce the allergic form of asthma.  At the same time, the herbal remedies had a lower level of toxicity than traditional medical treatments. Piperine interferes with the formation of uric acid crystals and the body’s immune response to them, making it a potential treatment for gout.
Piperine’s known anti-inflammatory effect may benefit those with a variety of auto-immune conditions. It can reduce inflammation tied to other causes, too, such as gingivitis.  That study recommends using piperine as a way to reduce inflammation in dental patients undergoing scaling and root planning, treatment for gum disease.
A clear benefit of using Bioperine over traditional anti-inflammatory drugs is the reduced risk of developing ulcers or internal bleeding.
Summary: Whether you have gout, asthma, arthritis or another inflammatory condition, piperine has something to offer you.
3. A Stimulated Metabolism
Piperine benefits include improved thermogenesis. That is the scientific term for the body’s production of heat from energy. Taking piperine can help your body burn more calories while digesting food without requiring any additional effort. Furthermore, the body burns more fat and protein to meet its needs.  This promotes weight loss over the long-term. As a side benefit, it reduces cholesterol levels without having a significant impact on blood sugar.
Summary: Piperine may help you reduce your cholesterol or burn fat without a lot of extra work.
4. Improved Mental Health
Curcumin and piperine together with antidepressant drugs were found to help those with depression better than those who only took antidepressants.  Patients in therapy for depression and/or anxiety had better outcomes when taking both piperine and curcumin than those who were not. This may be due to the animal studies that show piperine increases levels of serotonin and dopamine in the brain. Depressed patients are often deficient in these chemicals.
Curcumin alone reduces the toxicity of psychiatric drugs like haloperidol.  Combine curcumin with piperine to maximize the protective effects, assuming the piperine doesn’t negatively affect absorption of the drug.
Animal models suggest curcumin and piperine can slow the decline of mental abilities as we age.  There is some evidence piperine can improve attention and reasoning skills in healthy adults.  The biological processes behind these observed benefits are not yet known. However, these benefits are aside from the evidence that piperine aids those with depression and anxiety, conditions that can interfere with the executive function of the brain and energy levels.
One study of epileptic rats found that piperine supplements reduced their rate of memory impairment and oxidative stress.  While there are no reported studies of humans with epilepsy taking this herbal remedy, it literally cannot hurt and may prevent things from getting worse.
Summary: If you’re dealing with mental illness or deteriorating mental function with age, piperine may be of benefit.
5. The Reduction in Diabetes-Related Health Problems
Diabetes can be lethal in and of itself if left uncontrolled. Even when it is controlled, the slow toll of high or wildly fluctuating blood sugar wreaks havoc on the body. Diabetes is associated with an increased risk of blindness, digestive problems, kidney damage, and organ amputation. Anything we can do to prevent diabetes, reduce the risk of adverse side effects from the condition and better manage diabetes in those that develop it is all worth the effort. That is why curcuminoids plus piperine have been tested in combination to see how well they can aid patients with diabetes. 
Diabetic patients taking the mix of piperine and curcuminoids had a reduction in inflammatory TNF-α levels. This was true regardless of whether or not they lost weight. Their adiponectin levels went up. That is good because adiponectin is involved in regulating blood glucose levels.
In animal studies, piperine and curcumin showed the potential of preventing metabolic syndrome.  If true in humans, consumption of piperine supplements would reduce the odds developing metabolic syndrome, a condition that often progresses to diabetes. Piperine along with other traditional remedies shows potential in disrupting the progress of diabetes, as well.  In the lab, at least, piperine interfered with or outright reversed the molecular defects related to insulin resistance and glucose intolerance. More study is needed to understand how this happens and whether the results in the lab are seen in the human patient.
Curcuminoids have already been shown to reduce glycemia and related complications.  Addition of piperine to that regime could amplify the beneficial effects of the curcuminoids, such as the lower risk of liver damage when taking curcumin. Piperine does enhance curcuminoids’ anti-diabetes effect.
Summary: Piperine may help prevent diabetes but has been shown to reduce the toll the condition has on the body.
6. Improved Digestive Health
Piperine inhibits prostaglandins, hormone-like fats in the body.  This meant that piperine had an anti-diarrheal effect. These tests were scientific proof that piperine was useful as an antidiarrheal remedy. Whether you’re dealing with a stomach bug or irritable bowel syndrome, piperine has the potential to reduce your symptoms with minimal side effects.
Many people understand how inhaling cigarette smoke increases one’s odds of lung cancer and how eating and drinking toxic levels of alcohol are correlated to higher odds of developing stomach cancer. However, the opposite may be exactly as well – that taking certain supplements may reduce the odds of developing cancer in the digestive tract.  Bioperine and piperine in combination with curcumin were found to minimize mTORC1 chemical signaling in the intestinal wall. That expression is related to systematic inflammation in the digestive tract and an increased risk of cancer in the intestinal wall. If you already have an auto-immune condition that attacks the intestines, piperine may be of benefit to you, though you should consult with your doctor before taking piperine in conjunction with any other medication.
Summary: Piperine could be the key to keeping your digestive tract healthy.
7. Enhanced Workout Performance
Piperine, especially in conjunction with curcumin, helps protect the body from exercise-induced muscle damage and other harmful effects of a hard workout.  In a 2017 study, a mix of piperine and curcumin reduced the degree of exercise-induced muscle damage. The benefits were seen across many measures. Blood creatine kinase levels and muscle soreness were lower among those who took the supplements. Counter-movement jump performance, peak torque, and sprinting speeds were higher. Those who took the piperine and curcumin mix returned to their prior peak performance faster than those who didn’t. The herbal blend attenuated some but not all forms of muscle damage.
Summary: You’ll recover from workouts sooner due to reduced physical damage.
8. The Cancer-Fighting Potential
Piperine was among many natural compounds tested against triple-negative breast cancers, an unusually aggressive form.  These cancers don’t respond to conventional hormonal and growth factor-targeted interventions, leaving doctors with only cytotoxic drugs. Those drugs are only moderately active and often have unforeseen side effects. In the lab, combinations of piperine with other herbal remedies suppressed cancer cell growth, migration, inflammation, and metastasis. And it likely does so with fewer side effects.
On top of that, there was a 2008 study that suggested piperine inhibits the growth of colon cancer.
Summary: Piperine has the potential to help fight cancer.
A Word of Warning
Black pepper is incredibly well tolerated. That’s why it is one of the world’s most widely used spices. There’s almost no chance of experiencing an allergic reaction when consuming Bioperine supplements.
That doesn’t mean there aren’t concerns when taking piperine. Piperine can irritate the stomach and potentially cause bleeding, especially at high doses. Don’t take piperine supplements if you have ulcers or a delicate stomach. Piperine may have anti-platelet properties. Consult with your doctor if you have a blood clotting disorder or are taking blood thinners.
While piperine increases the absorption of nutrients in your diet, it may affect the absorption of other medications you’re taking, too. It can impact the removal of these drugs from the body, also. For example, piperine interferes in the glucuronidation process in the liver. That’s the process by which the body attaches glucuronide to drugs to signal the body to remove them once the compounds hit the kidney. Taking piperine can hinder the body’s ability to eliminate these drugs, leading to a build-up of the mixture. If you’re taking maintenance medication, ask your doctor if it is safe to take piperine. After all, elevated levels of a drug in the body may be good or bad, depending on the drug and your health condition.
Bioperine and piperine benefits include but are not limited to: improved nutrient absorption, reduced inflammation throughout the body, a stimulated metabolism with accelerated fat burning, improved mental health, faster recovery from hard workouts, a reduced risk of diabetes and its complications better digestive health, and the possibility of fighting multiple types of cancer.
Piperine is overwhelmingly safe, though the fact that it interferes with the removal of certain drugs from the body means you should talk to a doctor before taking piperine on top of medication.
 breast cancer
 metabolic syndrome
 epileptic rats